PDRN Skin Treatment: Rejuran vs Nucleofill – Benefits, Differences & Results
Aesthetic medicine is undergoing a global shift. Patients today are moving away from treatments that merely add volume or temporarily smooth lines, and toward therapies that repair, regenerate, and strengthen the skin from within. This evolution has brought PDRN (Polynucleotide) skin treatments to the forefront of modern regenerative aesthetics.
Two names dominate this space internationally: Rejuran and
Although both are PDRN-based injectable treatments, they work in distinctly different ways. Understanding these differences is essential—especially for patients in India and Delhi, where skin biology, pigmentation tendencies, climate, and pollution demand a more considered, doctor-led approach.
This comprehensive guide explains what PDRN skin treatment is, how Rejuran and Nucleofill compare, and how doctors determine which option is most suitable for each individual.
Rejuran vs Nucleofill – Quick Decision Guide
Primary skin concern | More suitable option |
|---|---|
Acne scars, rough texture, sensitivity | Rejuran |
Early ageing, laxity, reduced firmness | Nucleofill |
Skin repair & barrier recovery | Rejuran |
Bio-remodelling & elasticity | Nucleofill |
Both treatments use PDRN, but their clinical intent differs—repair versus bio-remodelling.
What Is PDRN Skin Treatment? (Polynucleotide Regenerative Therapy)
PDRN (Polydeoxyribonucleotide)
Clinically, PDRN skin treatment helps to:
- Stimulate fibroblast activity
- Improve collagen and elastin production
- Reduce inflammation
- Enhance tissue repair and skin resilience
This philosophy forms the backbone of regenerative aesthetics, where the goal is long-term skin health rather than short-term cosmetic correction.
Why PDRN Treatments Are Gaining Global Popularity
Globally, aesthetic medicine is moving away from aggressive correction and toward biologically respectful rejuvenation. PDRN treatments are increasingly preferred because they:
- Preserve natural facial expression
- Improve skin quality gradually
- Are suitable for sensitive or previously over-treated skin
In India, and particularly in metropolitan cities like Delhi, PDRN-based treatments are especially relevant due to higher exposure to UV radiation, pollution, heat, and inflammatory skin stress, all of which accelerate skin ageing and barrier damage.
What Is Rejuran? (A PDRN-Based Regenerative Injectable)
Rejuran – Composition & Science
Rejuran is derived from salmon DNA, processed to closely resemble human DNA, allowing effective integration into the skin’s repair mechanisms.
Key Benefits of Rejuran
- Improves skin texture and smoothness
- Helps repair acne scars
- Reduces redness and sensitivity
- Strengthens a compromised skin barrier
- Commonly used for under-eye rejuvenation
Who Is Rejuran Best Suited For?
- Younger to mid-age patients
- Acne-prone or post-acne skin
- Sensitive or inflamed skin
- Patients prioritising repair over lifting
Rejuran primarily targets skin repair and healing.
What Is Nucleofill? (Advanced Polynucleotide Bio-Remodelling)
Nucleofill – Composition & Science
Nucleofill uses highly purified polynucleotides developed to stimulate bio-remodelling, improving skin structure, hydration, and elasticity.
Key Benefits of Nucleofill
- Improves firmness and elasticity
- Enhances deep hydration
- Softens fine lines
- Supports early anti-ageing
Who Is Nucleofill Best Suited For?
- Mature or ageing skin
- Early laxity and thinning
- Patients seeking firmness without fillers
- Those wanting gradual rejuvenation
Nucleofill focuses on firmness, elasticity, and skin remodelling.
Rejuran vs Nucleofill – Clinical Differences Explained
Clinical Comparison Table (Doctor Interpretation)
Parameter | Rejuran | Nucleofill |
|---|---|---|
Core action | Repair & healing | Bio-remodelling |
Main focus | Texture, scars, sensitivity | Firmness, elasticity |
Typical age group | Younger–mid age | Mid-age onwards |
Skin type | Compromised / sensitive | Ageing / thinning |
Downtime | Mild | Minimal |
Clinical Interpretation of These Differences
Neither treatment is universally superior. They address different biological priorities, and selection depends on skin assessment rather than brand popularity.
Which PDRN Treatment Is Better for Indian Skin Types?
Indian skin commonly presents with:
- Higher pigmentation response
- Increased inflammatory tendency
- Environmental stress from heat and pollution
For patients exploring PDRN treatment in India, Rejuran is often preferred where skin repair and calming are priorities, while Nucleofill is chosen when firmness and early ageing are the main concerns.
In Delhi, where pollution and UV exposure are significant, PDRN protocols must be customised, not standardised.
PDRN Treatments for Men vs Women – Does Skin Response Differ?
Male and female skin responds differently to regenerative treatments.
- Men: Thicker skin, higher oil production, often require deeper or fewer sessions but longer intervals
- Women: Thinner skin, more collagen loss with age, may benefit from staged or combination protocols
PDRN treatments are effective for both, but dosage, spacing, and treatment planning differ, reinforcing the importance of doctor-led evaluation.
Doctor’s Perspective – How the Right PDRN Choice Is Made
At doctor-led aesthetic clinics, PDRN selection is based on:
- Skin thickness and sensitivity
- History of acne, pigmentation, or prior treatments
- Age-related structural changes
- Possibility of combination treatments (microneedling, lasers, skin boosters)
Rejuran and Nucleofill are not interchangeable injectables. They are tools used at different stages of a regenerative skin strategy.
PDRN Treatment Results – What to Expect
Timeline of Results
- 2–3 weeks: Improved hydration and skin comfort
- 4–6 weeks: Texture refinement and glow
- Long term: Stronger, healthier skin quality
Number of Sessions Required
- Rejuran: typically 3–4 sessions
- Nucleofill: usually 2–3 sessions
What PDRN Treatments Will NOT Do
- They do not replace fillers
- They do not create instant lifting
- They are not one-session miracle treatments
Their strength lies in progressive, natural regeneration.
Safety, Downtime & Why Doctor-Led PDRN Treatments Matter
When performed by trained doctors, PDRN treatments are safe. Mild redness or swelling may occur, but serious complications are rare.
In Delhi, India, choosing a doctor-led approach ensures:
- Proper patient selection
- Correct injection depth
- Ethical, medically sound planning
This is particularly important for regenerative injectables.
Frequently Asked Questions – Choosing Between Rejuran & Nucleofill
1. Is Rejuran better than Nucleofill?
Neither is universally better. Each addresses different skin concerns and biological goals.
2. Which PDRN treatment lasts longer?
Longevity depends on skin condition, number of sessions, and maintenance, rather than the product alone.
3. Can Rejuran and Nucleofill be combined in one plan?
Yes, in selected cases, as part of a staged regenerative approach.
Safety & Eligibility FAQs for PDRN Skin Treatments
4. Is PDRN safe for sensitive or acne-prone skin?
Yes, when properly selected and administered by a trained doctor.
5. Can PDRN replace fillers or Botox?
No. PDRN improves skin quality, not volume or muscle movement.
6. What is the downtime after treatment?
Most patients experience minimal downtime, with mild redness or swelling resolving within a few days.
Book a Personalised PDRN Skin Consultation
A personalised consultation allows your doctor to assess skin biology, lifestyle factors, and long-term goals before recommending Rejuran, Nucleofill, or a combination approach. This ensures safe, ethical, and sustainable outcomes.
PDRN Skin Treatment in Delhi, India – A Doctor-Led Approach
For patients considering Rejuran or Nucleofill treatment in Delhi, medical assessment is essential. At doctor-led clinics in Hauz Khas, South Delhi, PDRN protocols are planned only after evaluating skin behaviour, environmental exposure, and regenerative needs.
Final Thoughts – Rejuran vs Nucleofill Is Not About the Brand
PDRN treatments represent a global shift from cosmetic correction to true skin regeneration. The best results come not from choosing a popular name, but from selecting the right regenerative strategy for your skin.
