Polynucleotide Treatment in Delhi: Injections, Benefits & Cost
Polynucleotide treatment is an emerging injectable approach in aesthetic medicine, investigated for selected skin-quality concerns such as fine lines, texture and elasticity. Unlike conventional volumising dermal fillers, many polynucleotide formulations are considered primarily for skin-quality objectives rather than changing facial contours.
At The Face Clinic, Hauz Khas, South Delhi, Dr. Reema Arora provides individual assessment for patients exploring polynucleotide injections, including their potential benefits, limitations, safety considerations and alternatives.
Early clinical studies have reported promising outcomes in selected applications. However, the evidence remains limited. The Association of Cutaneous Surgeons of India’s 2026 consensus considers polynucleotide (PN) and polydeoxyribonucleotide (PDRN) treatments experimental and does not recommend their routine use on the available evidence.
Treatment decisions should therefore involve careful consideration of the specific formulation, its regulatory status, expected benefits, uncertainties and available alternatives.
This guide explains what polynucleotides are, their potential applications, treatment experience, recovery, results and polynucleotide injection cost in Delhi.
Considering Polynucleotide Injections?
Consult Dr. Reema Arora to understand whether an emerging injectable treatment is appropriate for your skin concern or whether another approach may be preferable.
Polynucleotide Injections at a Glance
Patient question | What to know |
What is polynucleotide treatment? | An injectable approach using selected purified DNA-derived formulations. |
What may it improve? | Certain measures of skin texture, elasticity and fine lines, although evidence remains limited. |
Where may it be considered? | Selected facial areas, including under-eye skin, and other areas supported by the specific formulation and clinical assessment. |
How is it performed? | Usually through multiple small injections using a product-appropriate technique. |
Is there downtime? | Temporary swelling, redness, tenderness, bruising or small injection-site bumps may occur. |
What does it cost? | At The Face Clinic, polynucleotide treatment costs ₹20,000–₹35,000 per session, depending on the product, area and treatment plan. |
Clinical note: Polynucleotide injections are not established routine treatment for all signs of skin ageing. Individual suitability, evidence quality and the availability of better-established alternatives must be considered.
What Are Polynucleotides and How Do They Work?
Polynucleotides (PN) are chains of nucleotides, the molecular building blocks of DNA and RNA.
Injectable PN products used in aesthetic practice commonly contain purified DNA-derived materials. Many are obtained from salmonid fish sources, although formulations vary in composition, molecular characteristics and physical properties.
Research has investigated their potential effects on tissue-response pathways, skin quality and extracellular-matrix biology.
These proposed effects help explain the interest in polynucleotide therapy. However, laboratory findings should not be interpreted as proof of predictable skin regeneration or guaranteed aesthetic improvement.
How May Polynucleotides Affect Skin Quality?
Studies have explored potential interactions involving fibroblast activity, tissue-repair processes and extracellular-matrix components.
Fibroblasts help maintain important structural components of the skin, including collagen.
However, a proposed collagen-related mechanism does not establish that every PN injection will increase collagen or visibly reverse skin ageing.
Clinical outcomes depend on the formulation, treatment protocol, skin condition and individual response.
Polynucleotides vs PDRN: What Is the Difference?
Polynucleotides (PN) and polydeoxyribonucleotide (PDRN) are related DNA-derived preparations.
Although the terms are sometimes used interchangeably, products may differ in their molecular characteristics, concentration, physical properties and intended clinical use.
Evidence obtained using one preparation should not automatically be generalised to another.
This page addresses the broader category of polynucleotide injections. For a formulation-specific explanation, see our PDRN skin treatment in Delhi guide.
Are Polynucleotide Injections Made From Salmon DNA?
Many commonly discussed PN formulations contain highly purified DNA-derived material obtained from salmon or trout sources.
This explains why patients may encounter the popular term salmon DNA injections.
The material’s origin does not by itself establish effectiveness, suitability or safety.
Patients with relevant allergies or concerns about animal-derived ingredients should discuss the composition of the exact product being considered.
For additional background, read salmon DNA injections explained.
What Can Polynucleotide Treatment Help Improve?
Interest in polynucleotides for skin centres on their potential role in selected aspects of skin-quality improvement.
Published studies have reported encouraging findings for certain outcomes, although the research is not yet sufficient to establish routine effectiveness across all products or indications.
Fine Lines and Early Skin Ageing
Some clinical studies have reported improvements in wrinkle-related measures following selected polynucleotide treatments.
This has generated interest in their possible use for superficial fine lines and early textural changes.
However, they should not be expected to reliably correct deep expression lines, pronounced folds or significant facial volume loss.
Skin Texture and Elasticity
Polynucleotide skin rejuvenation is being investigated for improvements in skin smoothness, elasticity and texture.
Responses may vary with the formulation, treatment protocol and baseline skin condition.
Improvements measured in clinical studies do not guarantee a visible or satisfactory outcome for every patient.
Crepey or Dehydrated-Looking Skin
Fine crepiness and changes in skin smoothness may prompt consideration of treatments aimed at skin quality.
Certain PN formulations have been studied for these concerns, but they are not automatically preferable to established hydration-focused approaches.
Where dehydration is the primary issue, an appropriate topical regimen or skin booster treatment in Delhi may be more relevant.
Under-Eye Fine Lines and Skin Quality
Selected PN formulations may be considered for concerns involving fine lines or crepey-looking under-eye skin.
However, dark circles and a tired appearance may arise from pigmentation, visible blood vessels, structural hollowing, eye bags, swelling or a combination of causes.
Polynucleotide treatment does not reliably correct all these problems.
A detailed anatomical assessment is particularly important in this delicate area.
For specific indications and limitations, read our polynucleotide eye treatment guide.
Can Polynucleotides Improve Acne Scars or Pigmentation?
Research into the use of PN/PDRN preparations for scars and pigmentation-related concerns remains limited.
Polynucleotide injections should not be presented as established standalone treatment for acne scarring, melasma or post-inflammatory hyperpigmentation.
These conditions require diagnosis and approaches selected according to their underlying causes.
Polynucleotide Treatment Areas: Face, Under-Eyes and Neck
The suitability of an anatomical area depends on the proposed formulation, treatment objective and available evidence.
Face: Selected concerns involving superficial fine lines, texture and skin-quality changes may be assessed.
Under-eyes: Thin or crepey-looking skin may prompt consideration of selected formulations, but pigmentation, structural hollowing and prominent bags require different assessment.
Neck: Fine lines or changes in skin texture may be evaluated, although the evidence and intended use of the specific product must be considered.
Other areas should not automatically be treated using a facial injection protocol.
A product being technically injectable into an area does not mean that treatment is clinically appropriate or supported by adequate evidence.
Who May Be Suitable for Polynucleotide Injections?
Polynucleotide treatment may be discussed with adults interested in selected skin-quality concerns who understand that the intervention remains emerging and that outcomes are uncertain.
Assessment should consider:
- The main skin concern and its underlying cause.
- The anatomy and condition of the proposed treatment area.
- Previous aesthetic procedures and treatment responses.
- Relevant medical history, medications and allergies.
- Product-specific precautions and contraindications.
- Expected benefits, available alternatives and realistic treatment goals.
When Might Polynucleotide Treatment Be Unsuitable?
Treatment may be inappropriate or require postponement when there is active infection, significant inflammation at the injection site, relevant product hypersensitivity or another contraindication.
Elective injectable treatment is generally deferred during pregnancy and breastfeeding because adequate safety data are lacking.
Additional assessment may be needed for patients with significant medical conditions, previous injectable complications or medicines affecting bleeding risk.
If the principal concern is substantial tissue laxity, prominent eye bags, deep folds or facial volume loss, another treatment pathway may be more suitable.
A consultation should establish whether PN offers sufficient potential benefit to justify its risks and uncertainties.
Which Polynucleotide Products Are Available at The Face Clinic?
The Face Clinic offers Rejuran and Nucleofill treatments as part of its wider range of injectable skin-quality options.
Both are associated with polynucleotide-based product families, but they should not be assumed to have identical formulations, intended uses or clinical evidence.
The exact product variant and suitability must be assessed individually.
Rejuran and Nucleofill: Why Product Selection Matters
Rejuran includes formulations marketed for selected skin-quality objectives.
Nucleofill is another polynucleotide-based product family with its own formulation characteristics and intended applications.
Differences between products may affect their physical behaviour, proposed use and supporting evidence.
The decision should therefore depend on the specific formulation and patient assessment—not simply brand recognition.
For a detailed comparison, read Rejuran vs Nucleofill.
Product-specific note: Regulatory status, permitted indications, composition and manufacturer instructions must be confirmed for the exact product proposed in India. Availability at a clinic should not be interpreted as proof of FDA or CDSCO approval for a particular aesthetic indication.
Polynucleotide Injection Cost in Delhi & India
At The Face Clinic, Hauz Khas, New Delhi, polynucleotide injections cost ₹20,000–₹35,000 per session.
The exact price depends on the selected formulation, treatment area and quantity required. Rejuran and Nucleofill formulations may have different pricing based on the specific product and proposed treatment plan.
The number of sessions, if any, is determined following individual clinical assessment. The total cost of a treatment course is discussed before proceeding.
What Determines Polynucleotide Injection Price?
Cost factor | How it affects pricing |
Product formulation | Different polynucleotide formulations, including Rejuran and Nucleofill products, may have different costs. |
Treatment area | The area being treated influences the quantity and technique required. |
Product quantity | The amount used depends on the specific formulation and treatment plan. |
Number of sessions | The overall treatment cost depends on whether additional sessions are clinically appropriate. |
Is Polynucleotide Treatment Priced Per Session?
Polynucleotide treatment pricing should be understood in relation to the specific product, amount administered and number of sessions proposed.
Patients considering a treatment course should confirm the cost of each session and the total estimated cost before proceeding.
What Does Polynucleotide Treatment Cost at The Face Clinic?
Polynucleotide treatment: ₹20,000–₹35,000 per session
The final quotation is provided following clinical assessment and confirmation of the formulation and treatment plan. Consultation charges, where applicable, are communicated separately.
Considering Polynucleotide Treatment in Delhi?
Consult Dr. Reema Arora at The Face Clinic, Hauz Khas, for an assessment of treatment suitability, formulation options, expected outcomes and costs.
What Happens During Polynucleotide Treatment?
Step 1: Consultation and Skin Assessment
Dr. Reema Arora assesses the treatment concern, skin condition, anatomy, medical history and individual goals.
The consultation helps distinguish skin-quality changes from pigmentation, structural ageing, volume loss or other conditions that may require different management.
Step 2: Formulation Review and Treatment Planning
If PN treatment is being considered, the specific formulation, rationale, available evidence, alternatives, risks and likely costs are discussed.
The patient should understand the limitations of the treatment before deciding whether to proceed.
Step 3: Preparing for Injections
Where treatment proceeds, the skin is assessed and prepared using appropriate infection-control measures.
Pain-management options, including suitable topical anaesthesia, may be discussed where appropriate.
Step 4: Administering Polynucleotide Injections
Depending on the product and anatomical area, the formulation may be delivered through multiple small injections.
Technique, depth, volume and distribution depend on the product and clinical plan.
Patients may experience temporary pinching, stinging or pressure during treatment.
Small injection-site elevations or papules may occur with some techniques.
Step 5: Immediate Recovery and Follow-Up
The treated area is reviewed, and individual aftercare instructions are provided.
The clinician explains expected short-term reactions, warning signs and any appropriate follow-up.
Additional sessions should be considered according to the specific product, the treatment rationale and the individual’s response.
Polynucleotide Treatment Results, Sessions and Longevity
Polynucleotide injections are not intended to produce an immediate facial lift or replace substantial lost volume.
Where a response occurs, improvements in selected aspects of skin quality may develop gradually.
When Might Polynucleotide Results Become Visible?
Clinical studies have assessed skin-quality outcomes over weeks and, in some cases, longer follow-up periods.
The timing and degree of improvement vary by formulation and patient.
Temporary swelling immediately after treatment should not be mistaken for a lasting improvement.
Not every patient experiences a visible or satisfactory result.
How Many Polynucleotide Sessions Are Usually Needed?
Some clinical protocols use multiple treatment sessions.
However, no universal session number or interval can be applied reliably to every PN product.
Treatment planning should reflect the proposed formulation, indication, available evidence and individual circumstances.
Patients should not assume that a predetermined package is necessarily appropriate.
How Long Do Polynucleotide Results Last?
Long-term aesthetic outcome evidence remains limited.
There is no single reliable longevity figure for all PN formulations.
Any decision about further treatment should follow reassessment of the observed response, ongoing objectives, risks and available alternatives.
Polynucleotide Injections: Side Effects, Recovery and Clinical Evidence
Polynucleotide injections are minimally invasive medical procedures and should not be described as risk-free.
What Side Effects Can Occur?
Short-term reactions may include:
- Redness or tenderness.
- Local swelling.
- Small raised injection-site bumps.
- Bruising.
- Temporary discomfort or sensitivity.
Less common complications may include infection, inflammatory reactions, persistent swelling, nodules or hypersensitivity.
The risk profile depends on the formulation, treatment area, injection technique and patient factors.
How Much Downtime Should Patients Expect?
Some patients may resume routine activities relatively soon, but visible swelling, bruising or injection-site bumps can persist after treatment.
Patients planning a social event should allow for possible visible recovery effects and follow the clinician’s guidance.
No universal zero-downtime claim is appropriate.
What Aftercare Is Recommended?
Aftercare instructions vary with the product and treatment area.
Patients may be advised to avoid unnecessary pressure or rubbing, temporarily modify irritating skincare, and follow individual guidance about exercise, heat exposure and other procedures.
Unexpected or worsening pain, spreading redness, fever, discharge or persistent unusual swelling require prompt medical assessment.
Sudden visual disturbance after a facial injection requires emergency medical attention.
What Does Scientific Research Say About Polynucleotide Injections?
The evidence is encouraging in selected applications but remains incomplete.
A systematic review of polynucleotides in aesthetic medicine reported promising findings involving selected aesthetic outcomes, while noting methodological limitations and the need for stronger studies.
A 2026 systematic review of PN and PDRN randomised trials included seven trials involving 183 participants.
Four studies evaluated skin rejuvenation, one postoperative scar prevention and two wound-healing applications.
This distinction is important. Results from wound-healing studies cannot be treated as direct proof of effectiveness for facial skin rejuvenation.
The review identified limitations including small study populations, differing treatment protocols and variable outcome measures.
What Is the Position of Indian Professional Guidelines?
The 2026 Association of Cutaneous Surgeons of India consensus statement evaluated PN/PDRN as an emerging dermatological modality.
The task force classified the evidence as Level 5, assigned a Grade D recommendation and considered PN/PDRN experimental, advising against routine clinical use on the current evidence.
It also highlighted limited long-term data, insufficiently standardised protocols and the need for appropriate precautions.
What this means for patients: PN treatment should not be presented as a standard, universally established rejuvenation procedure. Any consideration of its use requires careful assessment of product-specific evidence, medical suitability, regulatory status, risks and better-established alternatives.
Polynucleotides vs PDRN, Skin Boosters and Dermal Fillers
Injectable aesthetic treatments are not interchangeable merely because they may be discussed under the broad term skin rejuvenation.
Treatment | Principal consideration |
Polynucleotide injections | DNA-derived preparations under investigation for selected skin-quality applications. |
PDRN treatment | Related DNA-derived formulations studied for tissue-response and dermatological applications. |
Hyaluronic acid skin boosters | HA-based products used for selected hydration and skin-quality objectives. |
Anti-wrinkle injections | Used for appropriate muscle-driven expression lines. |
Volumising dermal fillers | Used for selected structural volume and facial contouring indications. |
Some polynucleotide formulations are themselves described as skin boosters or have filler-like physical characteristics.
The clinically relevant distinction is therefore the specific product and its intended objective, rather than a rigid classification based on marketing terminology.
How Is the Appropriate Treatment Selected?
A patient with dehydration may benefit from an appropriate skincare or hydration-focused approach.
Muscle-driven expression lines may require a different strategy from superficial skin-quality changes.
Facial volume loss may prompt an assessment of dermal filler treatment in Delhi, where clinically suitable.
Pigmentation, significant laxity, scarring and structural under-eye changes require cause-specific assessment.
The aim is to address the actual concern rather than select a treatment solely because it is currently popular.
Why Choose The Face Clinic for Polynucleotide Treatment in Delhi?
The Face Clinic is a doctor-led facial-aesthetics practice located in Hauz Khas, South Delhi.
Dr. Reema Arora, Founder and Medical Director, has more than 20 years of experience in facial aesthetics.
She holds an MBBS from St John’s Medical College, Bangalore, and an MSc in Facial Aesthetics from the UK.
Her professional background includes serving as Medical Head – Facial Aesthetics at Allergan India and experience in physician education and injectable aesthetic treatments.
Individual Assessment Before Product Selection
Different facial concerns require different treatment approaches.
At The Face Clinic, consultation focuses on identifying the underlying cause of the patient’s concern before discussing the suitability of a particular injectable.
This is especially important for emerging treatments, where the strength of clinical evidence may vary.
Formulation-Specific Treatment Considerations
PN, PDRN, Rejuran and Nucleofill should not be treated as interchangeable labels.
The proposed product, its composition, indication, evidence and precautions should be considered individually.
Treatment is not automatically recommended simply because a patient requests a popular injectable.
Informed Treatment Decisions
A meaningful consultation should explain the potential benefits and limitations of the proposed intervention, as well as alternative approaches.
In some cases, the appropriate recommendation may be a different treatment or no injectable procedure.
For a wider perspective on treatment selection, explore our anti-aging treatments in Delhi guide.
Frequently Asked Questions About Polynucleotide Treatment
1. What is polynucleotide treatment used for?
PN injections are being investigated for selected skin-quality concerns, including fine lines, texture and elasticity. Their clinical effectiveness depends on the formulation and indication, and the evidence does not currently establish routine use.
2. Are polynucleotide injections the same as dermal fillers?
Many PN formulations are considered for skin-quality objectives rather than conventional volume restoration. However, some PN products may have filler-like properties or be used as skin boosters, so the distinction depends on the exact formulation.
3. What is the polynucleotide injection price in Delhi?
At The Face Clinic, Hauz Khas, polynucleotide injections cost ₹20,000–₹35,000 per session. The exact price depends on the formulation, treatment area and quantity used. If multiple sessions are considered appropriate, the total treatment cost is explained during consultation.
4. How many polynucleotide treatment sessions are required?
There is no universal schedule. Some protocols use multiple sessions, but the appropriate number and intervals depend on product-specific information, the proposed indication and individual circumstances.
5. Can polynucleotides help under-eye wrinkles or dark circles?
Selected PN formulations may be considered for under-eye skin-quality concerns. They are not established treatments for every cause of dark circles, eye bags, pigmentation or structural hollowing.
6. Is polynucleotide treatment painful?
Temporary pinching, stinging or discomfort may occur during injections. Pain-management options depend on the product, treatment area and patient’s needs.
7. Can polynucleotides be combined with other treatments?
Combination treatment may occasionally be considered, but there is no basis for assuming that adding PN automatically improves results. The rationale, sequencing, cumulative risks and supporting evidence should be reviewed individually.
8. Are polynucleotide injections FDA-approved?
The ACSI’s 2026 position statement reports that PN/PDRN are not FDA-approved for any indication. Patients should not interpret international marketing claims, CE marking or commercial availability as proof of FDA approval.
The current Indian regulatory status of any exact product and proposed use must be verified separately.
Book a Polynucleotide Treatment Consultation in Delhi
Is Polynucleotide Treatment Appropriate for Your Skin?
If you are considering polynucleotide injections for skin rejuvenation, a doctor-led consultation can help clarify whether the treatment is relevant to your particular concern.
At The Face Clinic, Dr. Reema Arora provides individual assessment of skin changes, treatment suitability, available options, evidence limitations and proposed costs.
The objective is to support an informed decision—including when an established alternative or no injectable treatment may be preferable.
The Face Clinic — Dr. Reema Arora
LGF, C-36, Chaudhary Dilip Singh Marg
Hauz Khas Market, New Delhi – 110016
Clinic hours: Monday–Saturday, 10:00 AM–6:00 PM
Call: +91 99580 73900
WhatsApp: Enquire About Polynucleotide Treatment
Medical information notice: This page is intended for general education and does not replace an individual medical consultation. Polynucleotide treatments remain an emerging area of aesthetic medicine. Evidence, regulatory status, suitability, outcomes and risks vary between formulations and patients.
Medical reviewer: Dr. Reema Arora, MBBS, MSc Facial Aesthetics (UK), Founder & Medical Director, The Face Clinic.
Last medically reviewed: October 8, 2026
